Leaving food cooking overnight on a low setting in a Crock-Pot or other brands of electric pressure cookers like Instant Pot is generally not recommended from a food safety perspective. The reason is that leaving food in the "danger zone" temperature range for an extended period can promote the growth of harmful bacteria, which can lead to foodborne illnesses.
The "danger zone" refers to the temperature range between 40°F (4°C) and 140°F (60°C), where bacteria multiply most rapidly. Perishable foods left in this temperature range for more than two hours can become unsafe to eat.
Both Crock-Pots and electric pressure cookers are designed to cook food at a relatively low and slow pace, which is great for tenderizing meats and developing flavors. However, these devices may not be able to keep food at a safe temperature (above 140°F) for an extended period, especially when set on a low setting. There is a risk of the internal temperature of the food falling into the "danger zone" during the extended cooking time, especially if the food is dense or packed tightly in the cooking vessel.
To ensure food safety when using slow cookers or electric pressure cookers, follow these guidelines:
Don't leave food in the appliance for too long: It's best to avoid leaving food in a slow cooker or pressure cooker for longer than the recommended cooking time.
Use a timer: If possible, use the built-in timer on the appliance or an external timer to ensure that the cooking time is limited and that the food doesn't stay in the "danger zone" for too long.
Keep track of cooking times: Be aware of the recommended cooking times for different recipes and adjust accordingly to avoid overcooking or leaving food at unsafe temperatures.
Be cautious with perishable ingredients: If your recipe includes ingredients like meat, dairy, or eggs, it's essential to minimize the time they spend in the "danger zone." Precook these ingredients if necessary or use the high setting to bring the internal temperature up to safe levels more quickly.
Store leftovers properly: Once the cooking process is complete, promptly store any leftovers in the refrigerator or freezer to prevent bacterial growth.
Ultimately, it's crucial to prioritize food safety and follow recommended cooking guidelines to ensure that your meals are both delicious and safe to eat.