The baking time for a large Papa John's pepperoni pizza at 425 degrees Fahrenheit may vary slightly depending on the thickness of the crust, the amount of toppings, and the individual oven's performance. However, as a general guideline, a large pepperoni pizza typically takes around 12 to 15 minutes to bake at 425 degrees Fahrenheit.
It's essential to keep an eye on the pizza during the baking process to ensure it doesn't overcook or undercook. The crust should turn golden brown, the cheese should be melted and bubbly, and the pepperoni should be cooked and slightly crispy at the edges.
Since ovens can vary in temperature accuracy, it's a good idea to check the pizza after 10 minutes and then gauge whether it needs more time based on its appearance. Always follow any specific instructions provided by Papa John's for their pizzas to achieve the best results.